supporting information of alexy virgil bartberger and

Enantioselective Pd-Catalyzed Decarboxylative Allylic

Enantioselective Pd-Catalyzed Decarboxylative Allylic

Supporting Information for Alexy, Virgil, Bartberger, and Stoltz SI2 Materials and Methods Unless otherwise stated, reactions were performed in flame-dried glassware under an argon or nitrogen atmosphere using dry, deoxygenated solvents. Solvents were dried by passagesp.info Enantioselective Pd-Catalyzed Decarboxylative Allylic Alexy EJ 1, ' ' Virgil SC 1 Bartberger MD 2, Stoltz BM Journal Article, Research Support, N.I.H., Extramural DOI:10.1021/acslett.7b02354. Abstract. A catalytic, enantioselective decarboxylative allylic alkylation of 4-thiopyranones is reported. The α-quaternary 4-thiopyranones produced are challenging to access by standard enolate sp.info The Stoltz Group - Publications[Supporting Information]This article was Synfact of the Month! "Asymmetric Synthesis of QUINAP via Dynamic Kinetic Resolution" Vikram Bhat, Su Wang, Brian M. Stoltz, and Scott C Virgil. J. Am. Chem. Soc. 2013, 135, 16829. [Supporting Information]This article was featured in Synfacts!sp.info Synthesis, Characterization, and Optimization for in Vivo Bis-arylidenecycloalkanones structurally related to the nonselective isopeptidase inhibitor G5 were synthesized and tested for cytotoxic activity against glioblastoma cells. Cytotoxicities correlate well with Hammett σ constants for substituted arylidene groups, confirming the proposed inhibition mechanism. A new inhibitor (2c) based on the 4-hydroxycyclohexanone scaffold, which favors


			Enantioselective synthesis of highly oxygenated acyclic

Enantioselective synthesis of highly oxygenated acyclic

The development of a palladium-catalyzed enantioselective decarboxylative allylic alkylation of cyclic siloxyketones to produce enantioenriched silicon-tethered heterocycles is reported. The reaction proceeds smoothly to provide products bearing a quaternary stereocenter in excellent yields (up to sp.info Palladium-catalyzed enantioselective decarboxylative The first enantioselective palladium-catalyzed decarboxylative allylic alkylation of fully substituted N-acyl indole-derived enol carbonates forming acyclic all-carbon quaternary stereocenters is reported. Excellent yields up to 99% and enantioselectivities up to 98% ee are obtained through the use of a newsp.info Articles by Eric J. Alexy Journal of Chemical By Eric J. Alexy, Scott Virgil, Brian M. Stoltz, Michael D. Bartberger. pubs.acs — † Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology sp.info FBI — Former Louis Berger Group Inc. CEO Charged in NEWARK, NJ—The former president and CEO of New Jersey-based international engineering consulting company Louis Berger Group Inc. (LBG) surrendered to the FBI this morning to face a six-count indictment alleging he led a scheme to intentionally overbill the United States in connection with hundreds of millions of dollars in overseas reconstruction contracts over a nearly 20-year period, U.S


			Enantioselective synthesis of highly oxygenated acyclic

Enantioselective synthesis of highly oxygenated acyclic

Enantioselective synthesis of highly oxygenated acyclic quaternary center-containing building blocks via palladium-catalyzed decarboxylative allylic alkylation of cyclic siloxyketones†. Aurapat Ngamnithiporn‡ a, Toshihiko Iwayama‡ ab, Michael D. Bartberger c and Brian M. Stoltz * a a Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry sp.info Enantioselective Synthesis of α‐Secondary and α‐Tertiary Nov 07, 2014 · Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re‐organized for online delivery, but are not copy‐edited or typeset.sp.info (PDF) Incorporation of a chiral gem-disubstituted nitrogen All content in this area was uploaded by Michael Bartberger on Oct 23, 2019 Scott C. Virgil, a Jeff F. Miller, b and Brian M. Stoltz. a * supporting information for details). Table 4.sp.info Stoltz, Brian M - California Institute of Technology Translate this pageJ. Org. Chem. 2018, 83, 3467–3485. [Supporting Information]. "Nickel-Catalyzed Enantioselective Allylic Alkylation of Lactones and Lactams with Unactivated Allylic Alcohols" Fa Ngamnithiporn, Carina Jette, Shoshana Bachman, Scott Virgil, and Brian M. Stoltz. Chemical Science 2018, 9, 2547-2551. [Supporting Information].


			Palladium-catalyzed enantioselective decarboxylative

Palladium-catalyzed enantioselective decarboxylative

Palladium-catalyzed enantioselective decarboxylative allylic alkylation of fully substituted N-acyl indole-derived enol carbonates†. Eric J. Alexy‡ a, Tyler J. Fulton‡ a, Haiming Zhang * b and Brian M. Stoltz * a a Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena sp.info Brian M. Stoltz - PublicationsSun AW, Bulterys PL, Bartberger MD, Jorth PA, O'Boyle BM, Virgil SC, Miller JF, Stoltz BM. Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity. Bioorganic & Medicinal Chemistry Letters. PMID 33589 DOI:10.1016/j.bmcl.2019.07.024 :0.92:2019sp.info Synthesis and Optical Properties of Water‐Soluble Jul 02, 2013 · Abstract Four new water‐soluble polyglycerol‐dendronized perylene, terrylene, and quaterrylene bisimides have been synthesized and characterized with respect to sp.info Eric J. Alexy's research works California Institute of Eric J. Alexy's 11 research works with 107 citations and 197 reads, including:Global Diastereoconvergence in the Ireland–Claisen Rearrangement of Isomeric Enolates:Synthesis of


			Synthesis, Characterization and Optimization for in Vivo

Synthesis, Characterization and Optimization for in Vivo

To illustrate mining strategies supporting therapeutic studies, transcript eion was determined:1) relative to other models, 2) with successive in vivo passage, and 3) during the in vitro to sp.info Palladium-Catalyzed Decarboxylative Asymmetric Allylic Palladium-catalyzed decarboxylative asymmetric allylic alkylation (DAAA) of allyl enol carbonates as a highly chemo-, regio-, and enantioselective process for the synthesis of ketones bearing sp.info Enantioselective Pd-Catalyzed Decarboxylative Allylic Organic Letters DOI:10.1021/acslett.7b02354sp.info Stereospecific Overman Rearrangement of Substituted *S Supporting Information The Supporting Information is available free of charge on the ACS Publications website at DOI:10.1021/acs.or-glett.9b03347. Experimental procedures and characterization data (PDF) Accession Codes CCDC 1955048 contains the supplementary crystallographic data for this paper. These data can be obtained free of charge


			Enantioselective Total Synthesis of (–)-Myrifabral A and B

Enantioselective Total Synthesis of (–)-Myrifabral A and B

A catalytic enantioselective approach to the Myrioneuron alkaloids (−)-myrifabral A and (−)-myrifabral B is described. The synthesis was enabled by a palladium-catalyzed enantioselective allylic alkylation, that generates the C(10) all-carbon quaternary center. A key N-acyl iminium ion cyclization forged the cyclohexane fused tricyclic core, while vinyl boronate cross metathesis and sp.info Enantioselective Decarboxylative Alkylation Reactions α-Quaternary ketones are accessed through novel enantioselective alkylations of allyl and propargyl electrophiles by unstabilized prochiral enolate nucleophiles in the presence of palladium complexes with various phosphinooxazoline (PHOX) ligands. Excellent yields and high enantiomeric excesses are sp.info